| Total | Partidos | Victorias | Empates | Derrotas | |||
|---|---|---|---|---|---|---|---|
| Total | 451 | 178 | (39%) | 127 | (28%) | 146 | (32%) |
| Casa | 228 | 125 | (55%) | 59 | (26%) | 44 | (19%) |
| Fuera | 223 | 53 | (24%) | 68 | (30%) | 102 | (46%) |
| Item | Competición | Local | Visitante | |
|---|---|---|---|---|
| Mayor victoria en casa | Liga MX Clausura 2003/04 | Santos Laguna | 6-0 | CA Morelia |
| Clausura 2010 | Santos Laguna | 7-1 | CA Morelia | |
| Mayor victoria fuera | Clausura 2010 | Pachuca | 0-3 | Santos Laguna |
| Liga MX Clausura 2003/04 | Deportivo Irapuato | 0-3 | Santos Laguna | |
| Clausura 2015 | Chivas | 0-3 | Santos Laguna | |
| Mayor derrota fuera | Clausura 2005 | Chivas | 5-1 | Santos Laguna |
| Clausura 2019 | Monterrey | 4-0 | Santos Laguna | |
| Clausura 2010 | Chivas | 6-2 | Santos Laguna | |
| Liga MX Clausura 2002/03 | CA Morelia | 4-0 | Santos Laguna | |
| Mayor derrota en casa | Liga MX Clausura 2022/23 | Santos Laguna | 0-5 | Toluca |
