| 2022/10/31 | Philadelphia Union |  | 3-1 |  | New York City FC |
| 2022/10/30 | Los Angeles FC |  | 3-0 |  | Austin FC |
| P | GM | GR | Pts | |||
|---|---|---|---|---|---|---|
| 1 | | Philadelphia Union | 34 | 72 | 26 | 67 |
| 2 |  | CF Montréal | 34 | 63 | 50 | 65 |
| 3 | | New York City FC | 34 | 57 | 41 | 55 |
| 4 |  | NY Red Bulls | 34 | 50 | 41 | 53 |
| 5 |  | FC Cincinnati | 34 | 64 | 56 | 49 |
| 6 |  | Inter Miami CF | 34 | 47 | 56 | 48 |
| 7 |  | Orlando City | 34 | 44 | 53 | 48 |
| 8 |  | Columbus Crew | 34 | 46 | 41 | 46 |
| 9 |  | Charlotte FC | 34 | 44 | 52 | 42 |
| 10 |  | NE Revolution | 34 | 47 | 50 | 42 |
| 11 |  | Atlanta United | 34 | 48 | 54 | 40 |
| 12 |  | Chicago Fire | 34 | 39 | 48 | 39 |
| 13 |  | Toronto FC | 34 | 49 | 66 | 34 |
| 14 |  | DC United | 34 | 36 | 71 | 27 |
| P | GM | GR | Pts | |||
|---|---|---|---|---|---|---|
| 1 | | Los Angeles FC | 34 | 66 | 38 | 67 |
| 2 | | Austin FC | 34 | 65 | 49 | 56 |
| 3 |  | FC Dallas | 34 | 48 | 37 | 53 |
| 4 |  | LA Galaxy | 34 | 58 | 51 | 50 |
| 5 |  | Nashville SC | 34 | 52 | 41 | 50 |
| 6 |  | Minnesota United | 34 | 48 | 51 | 48 |
| 7 |  | Real Salt Lake | 34 | 43 | 45 | 47 |
| 8 |  | Portland Timbers | 34 | 53 | 53 | 46 |
| 9 |  | Vancouver Whitecaps | 34 | 40 | 57 | 43 |
| 10 |  | Colorado Rapids | 34 | 46 | 57 | 43 |
| 11 |  | Seattle Sounders | 34 | 47 | 46 | 41 |
| 12 |  | Sporting KC | 34 | 42 | 54 | 40 |
| 13 |  | Houston Dynamo | 34 | 43 | 56 | 36 |
| 14 |  | SJ Earthquakes | 34 | 52 | 69 | 35 |
 | |
|
| 2 |
|
Daniel Gazdag Philadelphia Union | 24 G |
| 3 |
|
Hany Mukhtar Nashville SC | 23 G |
| 4 |
|
Brandon Vázquez FC Cincinnati | 19 G |
| 5 |
|
Jesús Ferreira FC Dallas | 18 G |
| 2 |
|
Diego Fagundez Austin FC | 12 AST: |
| 2 |
|
Luciano Acosta FC Cincinnati | 12 AST: |
| 2 |
|
Carlos Vela Los Angeles FC | 12 AST: |
| 5 |
|
Carles Gil NE Revolution | 9 AST: |
