| Fase | Fecha | Hora | |||||
|---|---|---|---|---|---|---|---|
| 0 | 1/64 | FC Basel  | ANU |  Odense BK | 2021-02-24 | 16:00 | |
| 0 | 1/64 | Ajax | ANU | FK Krasnodar | 2021-03-01 | - | |
| 0 | 1/64 | Galatasaray | ANU | AZ Alkmaar | 2021-03-02 | 11:00 | |
| 0 | 1/64 | Borussia M´gladbach | ANU | Lazio | 2021-03-02 | 12:00 | |
| 0 | 1/64 | Chertanovo | ANU |  Maccabi Haifa | 2021-03-02 | 12:00 | |
| 0 | 1/64 | Apolonia Fier  | ANU |  Gyori ETO | 2021-03-02 | 13:30 | |
| 0 | 1/64 | Atalanta | ANU | RB Leipzig | 2021-03-02 | 13:30 | |
| 0 | 1/64 | Sparta Praha  | ANU | Benfica | 2021-03-02 | 14:00 | |
| 0 | 1/64 | Basaksehir | ANU | Club Brugge | 2021-03-02 | 14:00 | |
| 0 | 1/64 | Liverpool | ANU | Marseille | 2021-03-02 | 14:00 | |
| 0 | 1/64 | Juventus | ANU | Borussia Dortmund | 2021-03-02 | 15:00 | |
| 0 | 1/64 | Dynamo Kyiv | ANU | Barcelona | 2021-03-02 | 15:00 | |
| 0 | 1/64 | Manchester United | ANU | Real Madrid | 2021-03-02 | 16:00 | |
| 0 | 1/64 | Angers | ANU |  Crvena Zvezda | 2021-03-02 | 17:00 | |
| 0 | 1/64 | Sheriff  | ANU |  Kairat | 2021-03-02 | 17:00 | |
| 0 | 1/64 | Rangers | ANU | FC Köln | 2021-03-02 | 19:00 | |
| 0 | 1/64 | Zenit | ANU | Rennes | 2021-03-03 | 10:00 | |
| 0 | 1/64 | Shakhtar Donetsk | ANU | FC Porto | 2021-03-03 | 11:00 | |
| 0 | 1/64 | Lokomotiv | ANU | Ferencváros | 2021-03-03 | 12:00 | |
| 0 | 1/64 | Dinamo Minsk  | ANU |  Ludogorets Razgrad | 2021-03-03 | 13:00 | |
| 0 | 1/64 | APOEL | ANU |  Viitorul Constanta | 2021-03-03 | 14:00 | |
| 0 | 1/64 | Midtjylland | ANU | Atlético de Madrid | 2021-03-03 | 14:00 | |
| 0 | 1/64 | Olympiacos | ANU | Manchester City | 2021-03-03 | 14:00 | |
| 0 | 1/64 | Chelsea | ANU |  Red Bull Salzburg | 2021-03-03 | 14:00 | |
| 0 | 1/64 | Dinamo Zagreb  | ANU | Rosenborg | 2021-03-03 | 15:00 | |
| 0 | 1/64 | Genk | ANU |  MSK Zilina | 2021-03-03 | 15:00 | |
| 0 | 1/64 | Internazionale | ANU | Bayern München | 2021-03-03 | 16:00 | |
| 0 | 1/64 | Sevilla | ANU | Paris SG | 2021-03-03 | 16:00 | |
| 0 | 1/64 | Olimpija Ljubljana  | ANU | Celta de Vigo | 2021-03-03 | 17:00 | |
| 0 | 1/64 | Górnik Zabrze  | ANU | PAOK | 2021-03-03 | 19:00 | |
| 0 | 1/64 | Hammarby  | ANU |  Waterford | 2021-03-03 | 19:00 | |
| 0 | 1/64 | KF Shkendija 79  | ANU |  FK Qäbälä | 2021-03-04 | 13:30 |
